Adrian’s Generative Genomics Blog
Welcome to My Genomics Blog
This blog explores the intersection of genomics, generative modeling, and bioinformatics. Here you’ll find insights into cutting-edge research, computational methods, and their applications in understanding the genome.
Recent Posts
Squidiff: Conditional Diffusion for Single-Cell Perturbation Prediction - A synthesis of Squidiff’s semantic-conditioned diffusion model for developmental trajectories and perturbations (drugs, genetics, radiation), with comparisons to scGen and GEARS and notes on reproducibility.
A Synthesis of Multimodal Reasoning in Genomics - Exploring the paradigm shift from statistical associations to mechanistic biological understanding through BioReason and Genome-Bench in the context of GWAS.
Diffusion Models in Genomics: DNA-Diffusion and DiscDiff - An in-depth comparison of two cutting-edge diffusion models for genomic sequence generation, exploring their architectures, performance metrics, and implications for the future of generative modeling in genomics.
AlphaGenome Evolution: Advancing Regulatory Variant Prediction - A comprehensive exploration of AlphaGenome’s capabilities in regulatory variant prediction and its integration with advanced DNA language models for enhanced genomic modeling.
About This Blog
This blog serves as a platform for sharing insights from recent research papers, particularly focusing on computational genomics, generative modeling for single-cell data (including diffusion and perturbation prediction), and language-model applications in biology. Each post aims to provide both technical depth and accessible explanations of complex genomic concepts.
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